This time, the artist has painted an explicit portrait of Zuma featuring Nelson Mandela.
Mabulu has previously drawn criticism and support for some of his graphic artwork.
In taking aim at Zuma, a number of Mabulu's works feature the president in revealing or sexually explicit positions.
The painting has drawn widespread condemnation, with some people saying he's crossed a line by drawing Madiba in the way he has.
On Thursday afternoon, the conversation about the piece was growing on social media platforms.
See Mabulu's the latest painting below.
Me trying to unsee the latest Ayanda Mabulu 'art'. pic.twitter.com/Jz8LYUL9VB— Eusebius McKaiser (@Eusebius) April 20, 2017
Yhuuuu lo Ayanda Mabulu is one disgusting excuse of human being. pic.twitter.com/5Zpq9dkftZ— Mbongeni (@MGegana7) April 20, 2017
Knew it was to early to overreact to Zapiro's before Ayanda Mabulu drops.— Land-Now!!! (@azwiambeyi) April 20, 2017
South Africans taking Ayanda Mabulu out of the country after his latest form of expression. pic.twitter.com/tzL6t5JQ6n— Wasanga Mehana (@Wasanga_Mayhem) April 20, 2017
Even Ayanda Mabulu's thought process is disturbing.— S O B A H L E (@pearl_makhunga) April 20, 2017
Busy spewing bile. pic.twitter.com/hjjbo2aTXf
Ayanda Mabulu has some work to do if he wants 2 remain current of the changing situation in South Africa. Will the licker become the lickee?— steve (@honesttruth08) March 28, 2017
When some tweeps saw Tata on the Ayanda Mabulu painting! pic.twitter.com/vYktamxp5d— Tumi Sole (@tumisole) April 20, 2017
I don't care about zuma BUT to involve Mandela - it too much 😤 ...this ayanda mabulu guy 👎 pic.twitter.com/hnt1ROA2XO— Zulu queen 👑👢 (@nqobile_mhlungu) April 20, 2017
The weed Ayanda Mabulu smokes is excruciatingly strong. He also won't narrate what the painting is all about.— Kgomotso Motso Aphan (@MotsoAphane) April 20, 2017
What do you think of Ayanda Mabulu's artwork with Jacob Zuma and Nelson Mandela entitled "Economy of Rape"?— Songkran 🇿🇦 (@Cameo_Edwards1) April 20, 2017
RT after voting.
Ayanda Mabulu should hol up now... pic.twitter.com/gTFS1kExJH— KXNG BVDA (@SbudalatioN) April 20, 2017